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Netspot neoendocrine tumor santa fe9/19/2023 ![]() Neuroendocrine tumors (NETs) are heterogeneous neoplasms originating in diverse anatomical locations, including the lungs, liver, intestines, and adrenal glands. The results indicate that the bioreactor system and similar 3D culture models may be valuable tools for culturing patient-derived NETs and monitoring their response to therapy ex vivo. We also demonstrate that patient-derived NET tissues can be propagated using the bioreactor system and investigate the near-infrared (NIR) dye IR-783 for its use in monitoring their status within the bioreactor. Herein, we demonstrate the utility of the bioreactor system for culturing NET surrogates and provide methods for evaluating the efficacy of therapeutic agents on human NET cell line xenograft constructs and patient-derived NET surrogates. To address these limitations, we propose the use of an ex vivo 3D flow-perfusion bioreactor system for culturing and studying patient-derived NET surrogates. The lack of stable patient-derived NET xenograft models further limits the scientific community’s ability to make conclusions about NETs and their response to therapy in patients. 4Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United Statesįew models exist for studying neuroendocrine tumors (NETs), and there are mounting concerns that the currently available array of cell lines is not representative of NET biology.3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States. ![]() 2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.1Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States. ![]() Brendon Herring 1, Samuel Jang 1, Jason Whitt 1, Kayla Goliwas 2, Zviadi Aburjania 1, Vikas Dudeja 1, Bin Ren 1, Joel Berry 3, James Bibb 1, Andra Frost 4, Herbert Chen 1, John Bart Rose 1 and Renata Jaskula-Sztul 1* ![]()
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